disease:Defects in GLIS3 are a cause of NDH syndrome [MIM:610199]; also called neonatal diabetes mellitus with congenital hypothyroidism. NDH syndrome is a new neonatal diabetes syndrome associated with congenital hypothyroidism, congenital glaucoma, hepatic fibrosis and polycystic kidneys.,function:Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3'.,similarity:Belongs to the GLI C2H2-type zinc-finger protein family.,similarity:Contains 5 C2H2-type zinc fingers.,tissue specificity:In the adult, expressed at high levels in the kidney and at lower levels in the brain, skeletal muscle, pancreas, liver, lung, thymus and ovary.,

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