developmental stage:Expression in the endometrial epithelium fluctuates during the menstrual cycle, being greater during the secretory phase when compared with the proliferative phase.,disease:Defects in CABLES1 are associated with some colon and squamous cancers.,function:Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death.,induction:Up-regulated by progesterone and down-regulated by estrogen in benign endometrium.,PTM:Phosphorylated on Ser-313 by CCNE1/CDK3. Phosphorylated on serine/threonine residues by C

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