developmental stage:Low at birth, the cerebellin concentration increases between day 5 and 15, and reaches peak values between day 21 and 56.,function:Cerebellin exerts neuromodulatory functions. Directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release.,function:Cerebellin-1 is required for synapse integrity and synaptic plasticity. Required for the ER export and secretion of CBLN3.,PTM:The proteolytic processing to yield cerebellin seems to occur either prior to the secretion by presynaptic neurons and subsequent oligomerization or in some other location after release of the mature protein.,similarity:Contains 1 C1q domain.,subcellular location:Might be bound to, or associated with, a membrane.,subunit:Homohexamer;

非质量问题不退换