Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) whichisthe place in the synapse where neurotransmitter is released . After synthesis,participates in the formation of Golgi-derived membranous organellestermedPiccolo-Bassoon transport vesicles (PTVs) that are transported alongaxonstosites of nascent synaptic contacts . At the presynaptic active zone, regulatesthespatial organization of synaptic vesicle cluster, the protein complexesthat execute membrane fusion and compensatory endocytosis (By similarity). Functions also in processes other than assembly such as the regulationof specific presynaptic protein ubiquitination by interacting with SIAH1or theregulation of presynaptic autophagy by associating with ATG5 (By similarity).Mediates also synapse to nucleus communication leading to reconfigurationofgene expression by associating with the transcrip

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