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Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. ; [Isoform 1]: Efficiently hydrolyzes cAMP. ; [Isoform 2]: Efficiently hydrolyzes cAMP. ; [Isoform 3]: Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP. ; [Isoform 4]: Efficiently hydrolyzes cAMP. ; [Isoform 6]: Efficiently hydrolyzes cAMP. ; [Isoform 7]: Efficiently hydrolyzes cAMP.