FUNCTION: SwissProt: P51170 # Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.SIZE: 649 amino acids; 74270 Da SUBUNIT: Heterotetramer of two alpha, one beta and one gamma subunit. A delta subunit can replace the alpha subunit. Interacts with the WW domains of NEDD4, NEDD4L, WWP1 and WWP2.SUBCELLULAR LOCATION: Apical cell membrane; Multi-pass membrane protein. Note=Apical membrane of epithelial cells.PTM: Phosphorylated on serine and threonine residues (By similarity). & Ubiquitinated; this targets individual subunits for endocytosis and proteasome-mediated degradation (By similarity).DISEASE: SwissProt: P51170 # Defects in SCNN1G are a cause of Liddle syndrome [MIM:177200]. It is an autosomal dominant disorder characterized by pseudoaldosteronism and hypertension associated with hypokalemic alkalosis. The disease is caused by constitutive activation of the renal epithelial sodium channel.SIMILARITY: SwissProt: P51170 ## Belongs to the amiloride-sensitive sodium channel family.，官网链接：https://www.sigmaaldrich.cn/product/mm/ag340 默克 科研、开发、生产。 作为生命科学行业的全球领先供应商，我们致力于为科研、生物技术开发和生产，以及制药药物疗法开发和生产提供各类解决方案和服务。

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