Kinesin heavy chain isoform 5A, also known as Kinesin heavy chain neuron-specific 1 or Neuronal kinesin heavy chain (NKHC), and encoded by the gene name KIF5A or NKHC1, are members of the kinesin superfamily of proteins (KIFs). These proteins are microtubuledependent motors that slide along microtubules and transport cellular organelles and mRNA to different parts of the cell. In neurons, KIF5 performs this role in an anterograde fashion from the neuronal cell body to axonal or dendritic terminals. KIF5 was initially differentiated from the ubiquitously expressed kinesin as being highly enriched in subsets of neurons and selectively concentrated in the cell body. KIF5 has at least three known isoforms; KIF5A (117 kDa), KIF5B (39 kDa), and KIF5C (39 kDa). Mutations in one of the isoforms of KIF5 (KIF5A) is thought to be involved in hereditary spastic paraplegias，官网链接：https://www.sigmaaldrich.cn/product/mm/abt405 默克 科研、开发、生产。 作为生命科学行业的全球领先供应商，我们致力于为科研、生物技术开发和生产，以及制药药物疗法开发和生产提供各类解决方案和服务。

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