Calpain-6, also known as Calpain-like protease X-linked or Calpamodulin (CalpM) and encoded by the gene name CAPN6 or CALPM, belongs to a well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. This large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes as their activation can be triggered by calcium influx and oxidative stress. CAPN6 is most similar to Calpain 5; the C-terminal region of CAPN6 lacks homology to the calmodulin like domain of other vertebrate calpains. CAPN6 is thought to be involved in the regulation of microtubule dynamics and cytoskeletal organization. CAPN6 has also been recently identified as an HIV dependency factor (HDF), suggesting that CAPN6 may be an important drug target in HIV treatment.，官网链接：https://www.sigmaaldrich.cn/product/mm/abt404 默克 科研、开发、生产。 作为生命科学行业的全球领先供应商，我们致力于为科研、生物技术开发和生产，以及制药药物疗法开发和生产提供各类解决方案和服务。

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