Phosphatidylinositol 4-kinase beta (UniProt: Q9UBF8; also known as EC:2.7.1.67, PI4K-beta, PI4Kbeta, PtdIns 4-kinase beta, NPIK, PI4K92, PI4KIII) is encoded by the PI4KB (also known as PIK4CB) gene (Gene ID: 5298) in human. A group of four enzymes make up the mammalian phosphatidylinositol (PI) 4-kinase family are divided into two groups based on primary sequence and biochemical properties: consisting of type II (PI4KII and PI4KIIβ) and the type III (PI4KIII and PI4KIIIβ) isozymes. They all catalyze the phosphorylation of phosphatidylinositol (PI) at the D4 position of the inositol head-group to synthesize phosphatidylinositol 4-phosphate (PI4P) that serves as an essential precursor to produce PIP2 and PIP3. PI4-kinase b is a type III peripheral membrane protein that is present in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. It phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). It also regulates Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation and is involved in Golgi-to-plasma membrane trafficking. PI4-kinase b is shown to be critical for glucose-induced insulin secretion due to its capacity to regulate the release of secretory granules. In addition, it inhibits the insulin-stimulated translocation of glucose transporter-4 in adipocytes through its interaction with neuronal calcium sensor. (Ref.: Chalupska, D., et al. (2019). Sci. Rep. 9; article 567; Clyton, EL., et al. (2013). Prog. Lipid Res. 52(3); 294-304).，官网链接：https://www.sigmaaldrich.cn/product/mm/06578i 默克 科研、开发、生产。 作为生命科学行业的全球领先供应商，我们致力于为科研、生物技术开发和生产，以及制药药物疗法开发和生产提供各类解决方案和服务。

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