A cell-permeable benzothiazolo compound that acts a potent, selective, and reversible inhibitor of CKIδ (IC₅₀ = 290 nM). Exhibits much reduced potency towards CKIε and CKIα isoforms (IC₅₀ =1.3 and 2.5 µM, respectively). Does not affect the activity of CK2 or other kinases in a 59-protein kinase panel. Shown to block CKIδ-dependent period protein PER1 phosphorylation and diminish its proteasomal degradation in a dose-dependent manner. Also, shown to lengthen the circadian period in U2OS cells (10 h at 8 µM) without significantly affecting the amplitude of Per2-dLuc and Bmal1-dLuc rhythms.，官网链接：https://www.sigmaaldrich.cn/product/mm/218850 默克 科研、开发、生产。 作为生命科学行业的全球领先供应商，我们致力于为科研、生物技术开发和生产，以及制药药物疗法开发和生产提供各类解决方案和服务。

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