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A cell-permeable and reversible inhibitor of Hdm2 E3 ligase that selectively blocks Hdm2 E3-mediated ubiquitination. Has been shown to inhibit ubiquitination of p53 in vitro (IC₅₀ = 12.7 µM using Ub-Ubc as the donor substrate). Exhibits little effect towards other ubiquitin-using enzymes (IC₅₀ >100 µM for E1, Nedd-4, and SCF) or the auto-ubiquitination activity of Hdm2. The inhibition is non-competitive with respect to either the donor or acceptor substrate.，官网链接：https://www.sigmaaldrich.cn/product/mm/373225
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