A cell-permeable thiazolidinedione compound that acts as a potent, ATP-competitive, and isoform-selctive PI 3-K inhibitor (IC₅₀ = 0.07, 0.24, 1.45, and 1.70 M for the γ, α, β, and δ isoform, respectively) with little or no activity against a panel of 38 other commonly studied kinases (<20% inhibition at 1.0 M). Exhibits similar pharmacokinetics as LY 294002 in blocking rhRNATES-induced neutrophil peritoneal recruitment in mice in vivo. Also reported to exhibit significant in vivo prophylactic efficacy against carrageenan-induced tissue swelling in a rat paw edema model (100 mg/kg, p.o.).，官网链接：https://www.sigmaaldrich.cn/product/mm/528114 默克 科研、开发、生产。 作为生命科学行业的全球领先供应商，我们致力于为科研、生物技术开发和生产，以及制药药物疗法开发和生产提供各类解决方案和服务。

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