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β-Aminopropionitrile (BAPN) 是一种特异的、不可逆赖的、具有口服活性的氨酰氧化酶 (LOX) 抑制剂。β-Aminopropionitrile 靶向 LOX 或 LOXL 同工酶的活性位点。
生物活性
β-Aminopropionitrile (BAPN) is a specific, irreversible and orally active lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile targets the active site of LOX or LOXL isoenzymes[1][2].

IC50 & Target
Lysyl Oxidase

Human Endogenous Metabolite

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO IC50
0.31 μM
Inhibition of recombinant C-terminal His-tagged human LOXL3 (1 to 753 residues) expressed in CHO cells using cadaverine hydrochloride as substrate preincubated for 1 hr followed by substrate addition by ROS-Glo assay
[PMID: 31430136]
体外研究
(In Vitro)
β-Aminopropionitrile (BAPN) 可使 GLUT4 和脂联素的表达正常化，并在体外胰岛素抵抗模型中改善葡萄糖摄取[1]。
β-Aminopropionitrile（500 μM；72 小时）可阻断缺氧诱导的 EMT 形态和标志蛋白变化，并抑制宫颈癌细胞的体外侵袭和迁移能力[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

β-Aminopropionitrile 相关抗体:
BNSP Antibody
FACL4 Antibody
BrdU Antibody (YA578)
GAPDH Antibody
Glucose 6 Phosphate Dehydrogenase Antibody
METTL3 Antibody
TSG101 Antibody
Alkaline Phosphatase Antibody
Calnexin Antibody (YA573)
Lamin A/C Antibody
Lamin B1 Antibody
LAMP1 Antibody
LAMP2 Antibody (YA713)
LAMP2a Antibody
NQO1 Antibody (YA697)
NQO1 Antibody (YA261)
OPA1 Antibody
RBM3 Antibody
Synaptophysin Antibody (YA043)
Laminin beta 1 Antibody
Heme Oxygenase 1 Antibody
Ki67 Antibody (YA717)
Ki67 Antibody (YA322)
Asparagine Synthetase Antibody
Calnexin Antibody
Ki67 Antibody (YA001)
Osteopontin Antibody
Synaptophysin Antibody (YA664)
TREM2 Antibody
GAPDH Antibody (YA848)
Western Blot Analysis[1]

Cell Line: 3T3-L1 adipocytes
Concentration: 200 μM with 1.15 nM and 2.87 nM TNFα
Incubation Time: 72 h
Result: TNFα reduced expression of GLUT4 and adiponectin, and increased SOCS3 protein levels in these cells. And these effects were prevented.
体内研究
(In Vivo)
β-Aminopropionitrile (BAPN)（100 mg/kg/天；口服；6 周）可减少饮食引起的肥胖大鼠的体重增加并改善其代谢状况[1]。
β-Aminopropionitrile（1 g/kg/天；口服；4 周）可诱发 C57BL/6 小鼠胸主动脉夹层[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats of 150 g, high-fat diet (HFD) model[1]
Dosage: 100 mg/kg/day
Administration: In the drinking water, 6 weeks
Result: Significantly prevented the rise in body weight in HFD rats, but not in animals that were fed a standard diet. Reduced the increase in the weight of white adipose tissue (both epididymal and lumbar) in obese animals and attenuated their enhanced adiposity. Improved fasted glucose and insulin levels and consequently reduced HOMA index in the HFD group. Improved insulin signalling in adipose tissue from obese animals.
分子量
70.09

Formula
C3H6N2

CAS 号
151-18-8

性状
液体（密度：0.9584 g/cm3）

颜色
Colorless to light yellow

结构分类
Others
初始来源
微生物 内源性代谢物
运输条件
Room temperature in continental US; may vary elsewhere.

储存方式
-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)